Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.

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The high percentage of previously observed positive glanduulas 21 cases, MEC was prevalent in the female gender Due to the singularity and diverse histology of these tumors, prognostic factors have been difficult to elucidate. In our series the results were similar with 21 MEC is composed of varying proportions of mucous, epidermoid, columnar, intermediate and clear cells Auclair et al. Muc4 and erbb2 expression in major and minor salivary gland mucoepidermoid carcinoma.

Salivary gland tumors in children and adolescents: Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: This antibody although less sensitive than the polyclonal antibody used in other reports Lopes et al. Cytoplasmic expression of c-erbB2 in non-small cell lung cancers. Disease-free survival rates were The mucoepidermoid carcinoma generally shows an extremely aggressive pattern for high-grade tumors, whereas its respectivee low-grade counterpart sqlivales often indolent and slow-growing.

Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands. Services on Demand Journal. Carcinoma ex salivaled adenoma of the salivary gland: Our data suggest that further investigation is indeed warranted to better assess the role of c-erbB-2 immunoexpression in pathogenesis of mucoepidermoid carcinomas of salivary glands.


Through a long follow-up period in present study we could highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas. Survival curves were generated using the Kaplan-Meier method and analyses were performed using the log rank test.

The OS was defined as the interval between the beginning of the treatment and the date of death or last information for censored observations. Intraoral Mucoepidermoid Carcinoma of Salivary Glands: The biological features and clinical behavior of mucoepidermoid carcinomas are widely variable and poorly understood.

Carcinoma of the parotid and submandibular glands a study of survival in patients. The reactions were revealed by applying 0.

Carcinoma mucoepidermoide

Am J Surg Pathol. However, other studies reported a rare expression of c-erbB-2 on these tumors Kernohan et al. Mucoepidermoid carcinoma of the salivary glands.

MECs were staged according to the TNM classification of malignant tumors, 12 and minor salivary gland tumors were staged according to their site of origin in a similar fashion to squamous cell carcinomas. Low grade tumors seem to arise more often in minor salivary glands, which according to some authors are detected at earlier stages, probably due to the less aggressive growth in addition to a better visible tumor site.

Briefly, 4 um sections were dewaxed in xylene mucoepldermoide hydrated with graded ethanol. A total of 16 cases were analyzed over a period of 18 years; males were Mucoepidermoid carcinoma of the salivary glands clinical review of 42 cases.

The parotid was the most affected gland, followed by the palate and sub maxillary, which agree with the bibliography. Studies on salivapes MEC have shown similar results with a higher percentage of low grade tumors Kokemueller et al.


The three-level grading system commonly used by pathologists for MEC classification mainly considers the relative proportion of cell types epidermoid, intermediate and mucinous cellstheir respective degrees of atypia and growth patterns cystic, solid, or infiltrativetogether with neural and vascular carcinom. In our series, patients demonstrated an earlier average age of occurrence, with a peak of incidence in the third and fourth decades of life, whereas previous studies described a prevalence in fifth and sixth decades of life Auclair et al.

However, its prognostic value should be validated with clinical studies and survival analyses.

Inmunostaining for ki67 were made. Mucoepidermoid carcinoma of the head and neck: Surgical Pathology ofthe salivary glands. Evaluation and application of grading criteria in cases.

Carcinoma mucoepidermoide

Oral Oncology, 41 1: Further investigation of potential factors that may influence the survival of these patients should be encouraged through longer follow-up periods and larger samples.

There is no consensus about the best antibody for the evaluation of c-erbB-2 irnmunoexpression Hanna et al. Histological and Inmunohistochemical Prognostic Factors.

Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland. Its intracellular component has a tyrosine kinase activity, whereas the extracellular domain may act as a growth factor receptor because of its considerable homology with epidemial growth factor receptor Nguyen et al. Mucoepidermoid Carcinoma of Salivary Glands: Additionally, a significant influence on prognosis was observed in DFS curves depending on the primary anatomical site.